One invention in one sentence

[#5] Novel synthetic probes for diagnostic & therapy of infectious diseases.

J. MUZARD & al. Disclosed @ Nova UCD 2012 - Patent to be released in 2014

[#4] Invention & characterization of a set of synthetic & recombinant scaffolds for molecular manipulation & purification.

J. MUZARD & al. Patent EP11193316. [more]

[#3] Creation of a novel magnetic bio-nanomaterial for biotechnological applications. [Small, 2012]

J. MUZARD & G. U. LEE. Patent EP11150252. [more]

[#2] Invention of molecules for diagnostic of fibrosis: The first demonstration of fibrosis visualization in vivo & in real-time. [PLoS ONE, 2009]

J. MUZARD, P. BILLIALD & M. JANDROT-PERRUS. Polypeptides, cyclic polypeptides and pharmaceutical comprising thereof for non invasive specific imaging of fibrosis. Patent EP2008/067275 - WO2009/074628. [more]

[#1] Creation & development of neutralizing recombinant antibodies for therapeutic interventions in human thrombosis. [FEBS Journal, 2009 - Nature Biotechnology, 2011]

J. MUZARD, P. BILLIALD & M. JANDROT-PERRUS. Anti-glycoprotein VI scFv fragment for treatment of thrombosis. Patent EP2007/061569  - WO2008/049928. [more]


Coming soon...


[26] J. MUZARD* & P. BILLIALD. Engineering toxin-neutralizing antibody fragments & their therapeutic potential. Toxins, MDP Journals. [more]

[25] L.M. ALVARENGA, J. MUZARD, A. LEDREUX, C. BERNARD & P. BILLIALD. Colorimetric engineered immunoprobe for the detection and quantification of microcystins. Journal of Immunological Methods. [more]


[24] C. FIELDS, D. O'CONNELL, S. XIAO, G. LEE, P. BILLIALD & , J. MUZARD*. Creation of recombinant antigen-binding molecules derived from hybridomas secreting specific antibodies. Nature Protocols, 2013; 8; 6, 1125-1148. [more] Highlighted by UCD & MedicalXPress

[23] J. MUZARD*. Recent patent applications in computational biotechnologies. Nature Biotechnology, 2013; 31; 1:30. [more]

[22] E. R. BILLINGE, J. MUZARD & M. PLATT. Tunable resistive pulse sensing as a tool to monitor analyte induced particle aggregation. Nanomaterials & Nanosciences, 2013; 1; 1. [more]


[21] J. MUZARD*. Recent patent applications in single-molecule technologies. Nature Biotechnology, 2012; 30; 3:245. [more]

[20] E. MARTINES, J. MUZARD* & G. U. LEE. Single-Molecule Force Spectroscopy of the Aplysia Cell Adhesion Molecule Reveals Two Homophilic Bonds. Biophysical Journal, 2012; 103, 4, 649-657. [more]

[19] J. MUZARD*, C. FIELDS, J. O'MAHONY & G. U. LEE. Probing the soybean Bowman-Birk inhibitor using recombinant antibody fragments. J of Agricultural & Food Chemistry, 2012; 60: 6164-72.[more]

[18] J. MUZARD, M. PLATT & G. U. LEE. M13 Bacteriophage-Activated Superparamagnetic Beads for Affinity Separation. Small, 2012; 8; 2403-11. [more] Wiley Hot Topics - Journal Cover Art (2012.08) & "Article of the Month" (SFBBM)

[17] C. FIELDS, P. MALLEE, J. MUZARD* & G. U. LEE. Isolation of Bowman-Birk-Inhibitor from soybean extracts using novel peptide probes and high gradient magnetic separation. Food Chemistry, 2012; 134; 4:1831-38.[more]


[16] J. MUZARD*. Recent patent applications in antibody fragments: an academic update from the EU. Nature Biotechnology, 2011; 29; 11:979. [more]

[15] S. ADI-BESSALEM, J. MUZARD, P. BILLIALD & F. LARABA-DJEBARI. Recombinant antibody expression and purification: genetic engineering. Current Opinion in Biotechnology, 2011; 22S1. S61. [more]

[14] S. BHATTACHARYA, J. MUZARD, L. PAYET, J. MATHE, U. BOCKELMANN, A. AKSIMENTIEV & V. VIASNOFF. Rectification of the current in alpha-hemolysin pore depends on the cation type: the alkali series probed by MD simulations and experiments. Journal of Physical Chemistry C, Nanomater Interfaces, 2011; 115; 10:4255-4264. [more]


[13] M. ZAHID, S. ADI-BESSALEM, J. MUZARD & al. Scorpion antivenoms: progresses and challenges. Advances & new technologies in Toxinology, SFET Editions. E-book. [more]

[12] V. VIASNOFF, N. CHIARUTTINI, J. MUZARD & U. BOCKELMANN. Force fluctuations assist nanopore unzipping of DNA. J. Phys.: Condens. Matter, 2010; 22:454122. [more]

[11] J. MUZARD, M. MARTINHO, J. MATHE, U. BOCKELMANN & V. VIASNOFF. DNA translocation and unzipping through a nanopore: some geometrical effects. Biophysical Journal, 2010; 19; 98:2170-8. [more]


[10] J. MUZARD, M. BOUADBELLI, M. ZAHID, V. OLLIVIER, JJ. LACAPERE, M. JANDROT-PERRUS & P. BILLIALD. Design and humanization of a murine scFv which blocks human platelets glycoprotein VI in vitro. The FEBS Journal, 2009; 276:4207-22. Selected for Virtual Issue of FEBS Journal, 2012 [more]

[9] J. MUZARD, L. SARDA-MANTEL, S. LOYAU, A. MEULEMANS, L. LOUEDEC, C. BANTSIMBA-MALANDA, F. HERVATIN, J. MARCHAL-SOMME, JB. MICHEL, D. LE GULUDEC, P. BILLIALD & M. JANDROT-PERRUS. Non-Invasive Molecular Imaging of Fibrosis Using a Collagen-Targeted Peptidomimetic of the Platelet Collagen Receptor Glycoprotein VI. PLoS ONE, 2009; 4(5):e5585. [more]

[8] J. MUZARD, S. ADI-BESSALEM, M. JUSTE, F. LARABA-DJEBARI, N. AUBREY & P. BILLIALD. Grafting of Protein L-binding activity onto recombinant antibody fragments. Anal Biochem, 2009; 388:331-8. [more]


[7] M. JANDROT-PERRUS, J. MUZARD & al. Identification and Characterization of a Human Platelet Glycoprotein VI Peptidomimetic Permitting Molecular Imaging of Fibrosis. Blood, 2008; 112 ; 11:644-645.


[6] J. MUZARD. Generation and characterization of a recombinant blocking anti-glycoprotein VI single-chain antibody fragment. Human Antibodies, 2006 ;15 ; 1-2:24.

[5] J. MUZARD, S. LOYAU, N. AJZENBERG, P. BILLIALD & M. JANDROT-PERRUS. Antithrombotic recombinant antibodies. J Soc Biol, 2006; 200:365-376.

[4] N. AUBREY, J. MUZARD, M. JUSTE & P. BILLIALD. Recombinant antibodies: towards a new generation of antivenoms. J Soc Biol, 2006; 200:345-354.

[3] M. JUSTE, J. MUZARD & P. BILLIALD. Cloning of the antibody kappa light chain V-gene from murine hybridomas by bypassing the aberrant MOPC21-derived transcript. Anal Biochem, 2006; 349:159-61. [more]


[5] J. MUZARD, P. BILLIALD, M. GOYFFON & N. AUBREY. Recombinant antibodies : a new application in scorpion envenomation? Bull Soc Pathol Exot, 2005; 98:383-5.


[1] N. AUBREY, J. MUZARD, J.C. PETER, H. ROCHAT, M. GOYFFON, C. DEVAUX & P. BILLIALD. Engineering of a recombinant Fab from a neutralizing IgG directed against scorpion neurotoxin AahI and functional evaluation versus other antibody fragments. Toxicon, 2004; 43 (3):233-41. [more]